Organization for DESIGN THE FUTURE
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EFFORTS OF UNIVERSITY OF TSUKUBAEfforts of University of Tsukuba

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Project

Regenerative Treatment Research Through Neural Stem Cells Extracted from Intraoral Mesenchymal Cells

Summary

In Japan, an estimated 186,000 people suffer cerebral infarction per year. Despite acute phase treatment and rehabilitation, many patients suffer from speech disorders, paralysis and other secondary effects that prevent them from returning home or reintegrating into society. Stroke, including cerebral infarction, is the third highest cause of death. Furthermore, spinal cord injury and nerves damage restrict daily life by impairing limb motor sensory.

 

In order to treat cerebral infarction, spinal cord injury, nerve damage and other neurological disorders, neural stem cells are extracted from intraoral mesenchymal cells (dental pulp, gums, and buccal fat pads) and used to research regenerative medicine. We prepare neural stem cells from intraoral mesenchymal cells and various differentiated neural cells to examine therapeutic results as a regenerative treatment for cerebral infarction. From those same cells, we construct nerve bundles and develop never transplant treatments for spinal cord injury and nerve damage.

 

Induced differentiation of intraoral mesenchymal cells

Neural cell spheroid

Creation of a nerve bundle

Company
Bio-functional Control and Regenerative Research Group
Main member

MATSUMURA Akira

Professor, Faculty of Medicine

BUKAWA Hiroki

Professor, Faculty of Medicine

MATSUMARU Yuji

Professor, Faculty of Medicine

MARUSHIMA Aiki

Lecturer, Faculty of Medicine

ISHIKAWA Hiroshi

Researcher, Faculty of Medicine

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