Organization for DESIGN THE FUTURE
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EFFORTS OF UNIVERSITY OF TSUKUBAEfforts of University of Tsukuba

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Project

Development of Immunotherapy Targeting Immunoreceptors for Treatment of Intractable Immune Diseases

Summary

Immunoreceptors are cell-surface molecules expressed on a variety of immune cells and regulate activation of these cells through transmitting either activating or inhibitory signals. Therefore, immunoreceptors play a pivotal role in immune responses against infectious disease, cancer, inflammation, and allergy. In order to establish therapeutic approaches against these disorders, it is essential to regulate the immunoreceptor-mediated signaling. Our group first identified the immnunoreceptors, including DNAM-1 (CD226), MAIR (CD300), Allergin-1, and Fcα/μR (CD351), which play important roles in the pathogenesis of cancer, inflammation, allergy, and infection, respectively. In this research, we will develop drugs that target these immunoreceptors.

 

By using disease model mice, we have clarified that DNAM-1 is involved in the development of cancer, acute graft versus host disease (GVHD), and organ transplant rejection; MAIR in sepsis, inflammatory bowel disease, atopy and asthma; Allergin-1 in anaphylaxis and atopy; and Fcα/μR in sepsis and autoimmune diseases. Moreover, monoclonal antibodies against these immunoreceptors exhibited therapeutic efficacies in disease model mice. Our goal is to create humanized antibodies against these immunoreceptors for clinical application.

 

 

Press releases, etc.
1) DNAM-1 (CD226)

2) MAIR (CD300)

3) Allergin-1 (CD351)

4) Fcα/μR (CD351)

Further information

Company
Life Science Center for Survival Dynamics
Main member

SHIBUYA Akira

Professor, Life Science Center for Survival Dynamics

SHIBUYA Kazuko

Associate Professor, Faculty of Medicine

HANAOKA Tahara Satoko

Lecturer, Life Science Center for Survival Dynamics

ODA Nakahashi Chigusa

Assistant Professor, Faculty of Medicine

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